Affiliation:
1. National Institute for Medical Research, Mill Hill, London NW7 1AA, UK.
Abstract
A gene encoding a zinc finger protein of the
Snail
family,
cSnR
, is expressed in the right-hand lateral mesoderm during normal chick development. Antisense disruption of
cSnR
function during the hours immediately preceding heart formation randomized the normally reliable direction of heart looping and subsequent embryo torsion. Implanted ectopic sources of intercellular signal proteins that are involved in establishing normal left-right information randomized the handedness of heart development and also altered the asymmetry of
cSnR
expression.
cSnR
thus appears to act downstream of these signals, or perhaps in parallel with the latest expressed of them, the Nodal protein, in controlling the anatomical asymmetry.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
187 articles.
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