The human transcriptome across tissues and individuals

Author:

Melé Marta12,Ferreira Pedro G.1345,Reverter Ferran167,DeLuca David S.8,Monlong Jean179,Sammeth Michael1710,Young Taylor R.8,Goldmann Jakob M1711,Pervouchine Dmitri D.1712,Sullivan Timothy J.8,Johnson Rory17,Segrè Ayellet V.8,Djebali Sarah17,Niarchou Anastasia345,Consortium The GTEx,Wright Fred A.13,Lappalainen Tuuli3451415,Calvo Miquel6,Getz Gad816,Dermitzakis Emmanouil T.345,Ardlie Kristin G.8,Guigó Roderic171718

Affiliation:

1. Center for Genomic Regulation (CRG), Barcelona, Catalonia, Spain.

2. Harvard Department of stem cell and regenerative biology, Harvard University, Cambridge, MA, USA.

3. Department of Genetic Medicine and Development, University of Geneva, Geneva, Switzerland.

4. Institute for Genetics and Genomics in Geneva (iGE3), University of Geneva, Geneva, Switzerland.

5. Swiss Institute of Bioinformatics, Geneva, Switzerland.

6. Facultat de Biologia, Universitat de Barcelona (UB), Barcelona, Catalonia, Spain.

7. Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, Spain.

8. Broad Institute of MIT and Harvard, Cambridge, MA, USA.

9. McGill University, Montreal, Canada.

10. National Institute for Scientific Computing (LNCC), Petropolis, Rio de Janeiro, Brazil.

11. Radboud University, Nijmegen, Netherlands.

12. Faculty of Bioengineering and Bioinformatics, Moscow State University, Leninskie Gory 1-73, 119992 Moscow, Russia.

13. North Carolina State University, Raleigh, NC, USA.

14. New York Genome Center, New York, NY, USA.

15. Department of Systems Biology, Columbia University, New York, NY, USA.

16. Cancer Center and Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.

17. Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Barcelona, Catalonia, Spain.

18. Joint CRG-Barcelona Super Computing Center (BSC)–Institut de Recerca Biomedica (IRB) Program in Computational Biology, Barcelona, Catalonia, Spain.

Abstract

Expression, genetic variation, and tissues Human genomes show extensive genetic variation across individuals, but we have only just started documenting the effects of this variation on the regulation of gene expression. Furthermore, only a few tissues have been examined per genetic variant. In order to examine how genetic expression varies among tissues within individuals, the Genotype-Tissue Expression (GTEx) Consortium collected 1641 postmortem samples covering 54 body sites from 175 individuals. They identified quantitative genetic traits that affect gene expression and determined which of these exhibit tissue-specific expression patterns. Melé et al. measured how transcription varies among tissues, and Rivas et al. looked at how truncated protein variants affect expression across tissues. Science , this issue p. 648 , p. 660 , p. 666 ; see also p. 640

Funder

United States National Institutes of Health

National Institute of Mental Health

National Institute on Drug Abuse

National Heart, Lung, and Blood Institute

National Human Genome Research Institute

National Cancer Institute

National Institute of Neurological Disorders and Stroke

European Research Council

Louis-Jeantet Foundation

Swiss National Science Foundation

University of North Carolina-Chapel Hill

Spanish Ministerio de Ciencia e Innovación

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3