Single–Base Pair Unwinding and Asynchronous RNA Release by the Hepatitis C Virus NS3 Helicase-Reference-Cited by-同舟云学术

Single–Base Pair Unwinding and Asynchronous RNA Release by the Hepatitis C Virus NS3 Helicase

Published:2011-09-23 Issue:6050 Volume:333 Page:1746-1749
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cheng Wei¹,Arunajadai Srikesh G.²,Moffitt Jeffrey R.³,Tinoco Ignacio⁴,Bustamante Carlos⁴⁵

Affiliation:

1. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA.

2. Department of Biostatistics, Columbia University, New York, NY 10032, USA.

3. Harvard University Center for Systems Biology, Cambridge, MA 02138, USA.

4. Department of Chemistry, University of California, Berkeley, CA 94720, USA.

5. QB3 Institute and Jason L. Choy Laboratory of Single Molecule Biophysics, Department of Molecular and Cellular Biology, Department of Physics, and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA.

Abstract

During RNA unwinding, nucleotides are transiently sequestered, and their release is decoupled from base pair opening.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference28 articles.

1. Non-hexameric DNA helicases and translocases: mechanisms and regulation

2. RNA helicases at work: binding and rearranging

3. Crystal Structures of Complexes of PcrA DNA Helicase with a DNA Substrate Indicate an Inchworm Mechanism

4. Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism

5. Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV

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