Affiliation:
1. Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
2. The Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
3. Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Abstract
Providing for protein synthesis
Compartmentalization of metabolic processes into organelles can have important consequences. Zhu
et al.
examined the role of the coenzyme nicotinamide adenine dinucleotide phosphate (NADP
+
) and its reduced form (NADPH) in cultured human cells. They found that cells lacking NAD kinase 2, an enzyme needed to make NADPH, had decreased abundance of mitochondrial NADPH and proliferated slowly in culture medium with limited nutrients because of a lack of proline. Proline is made in the mitochondria, and thus a key function of NADPH in the mitochondria appears to be the synthesis of proline to sustain cellular protein synthesis.
Science
, abd5491, this issue p.
968
Funder
National Institutes of Health
National Cancer Institute
National Institute of Allergy and Infectious Diseases
Hunter Douglas Fellowship in Breast Cancer Research
BRIA Postdoctoral Researcher Innovation Grant
Human Frontier Science Program
Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center
European Molecular Biology Organization
Leukemia and Lymphoma Society
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
65 articles.
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