Affiliation:
1. Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, England, UK.
Abstract
Mechanism of ribosome rescue
Bacterial ribosomes that stall on truncated or cleaved messenger RNA (mRNA) are rescued by trans-translation. Two factors, transfer-messenger RNA (tmRNA) and small protein B (SmpB), resolve the stalled complex by tagging the nascent polypeptide for degradation and facilitating release of the ribosome. Rae
et al.
determined structures of key trans-translation intermediates. The structures reveal how SmpB identifies stalled ribosomes; how the large, circularized tmRNA molecule moves through the ribosome; and how translation is shifted from the truncated mRNA to tmRNA.
Science
, this issue p.
740
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
31 articles.
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