Aging increases cell-to-cell transcriptional variability upon immune stimulation-Reference-Cited by-同舟云学术

Aging increases cell-to-cell transcriptional variability upon immune stimulation

Published:2017-03-31 Issue:6332 Volume:355 Page:1433-1436
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Martinez-Jimenez Celia Pilar¹²^ORCID,Eling Nils¹³^ORCID,Chen Hung-Chang¹^ORCID,Vallejos Catalina A.³⁴^ORCID,Kolodziejczyk Aleksandra A.²³^ORCID,Connor Frances¹^ORCID,Stojic Lovorka¹^ORCID,Rayner Timothy F.¹^ORCID,Stubbington Michael J. T.³^ORCID,Teichmann Sarah A.²³^ORCID,de la Roche Maike¹,Marioni John C.¹²³^ORCID,Odom Duncan T.¹²^ORCID

Affiliation:

1. University of Cambridge, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge CB2 0RE, UK.

2. Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.

3. European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.

4. Medical Research Council Biostatistics Unit, Cambridge Institute of Public Health, Forvie Site, Robinson Way, Cambridge Biomedical Campus, Cambridge CB2 0SR, UK.

Abstract

Single-cell sequencing of mouse immune cells reveals how aging destabilizes a conserved transcriptional activation program.

Funder

European Molecular Biology Organization

Wellcome Trust

Cancer Research UK

European Molecular Biology Laboratory

European Research Council

Medical Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject