The
Chlamydomonas
Genome Reveals the Evolution of Key Animal and Plant Functions
Author:
Merchant Sabeeha S.12345, Prochnik Simon E.12345, Vallon Olivier12345, Harris Elizabeth H.12345, Karpowicz Steven J.12345, Witman George B.12345, Terry Astrid12345, Salamov Asaf12345, Fritz-Laylin Lillian K.12345, Maréchal-Drouard Laurence12345, Marshall Wallace F.12345, Qu Liang-Hu12345, Nelson David R.12345, Sanderfoot Anton A.12345, Spalding Martin H.12345, Kapitonov Vladimir V.12345, Ren Qinghu12345, Ferris Patrick12345, Lindquist Erika12345, Shapiro Harris12345, Lucas Susan M.12345, Grimwood Jane12345, Schmutz Jeremy12345, Cardol Pierre12345, Cerutti Heriberto12345, Chanfreau Guillaume12345, Chen Chun-Long12345, Cognat Valérie12345, Croft Martin T.12345, Dent Rachel12345, Dutcher Susan12345, Fernández Emilio12345, Fukuzawa Hideya12345, González-Ballester David12345, González-Halphen Diego12345, Hallmann Armin12345, Hanikenne Marc12345, Hippler Michael12345, Inwood William12345, Jabbari Kamel12345, Kalanon Ming12345, Kuras Richard12345, Lefebvre Paul A.12345, Lemaire Stéphane D.12345, Lobanov Alexey V.12345, Lohr Martin12345, Manuell Andrea12345, Meier Iris12345, Mets Laurens12345, Mittag Maria12345, Mittelmeier Telsa12345, Moroney James V.12345, Moseley Jeffrey12345, Napoli Carolyn12345, Nedelcu Aurora M.12345, Niyogi Krishna12345, Novoselov Sergey V.12345, Paulsen Ian T.12345, Pazour Greg12345, Purton Saul12345, Ral Jean-Philippe12345, Riaño-Pachón Diego Mauricio12345, Riekhof Wayne12345, Rymarquis Linda12345, Schroda Michael12345, Stern David12345, Umen James12345, Willows Robert12345, Wilson Nedra12345, Zimmer Sara Lana12345, Allmer Jens12345, Balk Janneke12345, Bisova Katerina12345, Chen Chong-Jian12345, Elias Marek12345, Gendler Karla12345, Hauser Charles12345, Lamb Mary Rose12345, Ledford Heidi12345, Long Joanne C.12345, Minagawa Jun12345, Page M. Dudley12345, Pan Junmin12345, Pootakham Wirulda12345, Roje Sanja12345, Rose Annkatrin12345, Stahlberg Eric12345, Terauchi Aimee M.12345, Yang Pinfen12345, Ball Steven12345, Bowler Chris12345, Dieckmann Carol L.12345, Gladyshev Vadim N.12345, Green Pamela12345, Jorgensen Richard12345, Mayfield Stephen12345, Mueller-Roeber Bernd12345, Rajamani Sathish12345, Sayre Richard T.12345, Brokstein Peter12345, Dubchak Inna12345, Goodstein David12345, Hornick Leila12345, Huang Y. Wayne12345, Jhaveri Jinal12345, Luo Yigong12345, Martínez Diego12345, Ngau Wing Chi Abby12345, Otillar Bobby12345, Poliakov Alexander12345, Porter Aaron12345, Szajkowski Lukasz12345, Werner Gregory12345, Zhou Kemin12345, Grigoriev Igor V.12345, Rokhsar Daniel S.12345, Grossman Arthur R.12345
Affiliation:
1. Department of Chemistry and Biochemistry, University of California at Los Angeles, Los Angeles, CA 90095, USA. 2. U.S. Department of Energy (DOE) Joint Genome Institute (JGI), Walnut Creek, CA 94598, USA. 3. CNRS, Université Paris 6, Institut de Biologie Physico-Chimique, 75005 Paris, France. 4. Department of Biology, Duke University, Durham, NC 27708, USA. 5. Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Abstract
Chlamydomonas reinhardtii
is a unicellular green alga whose lineage diverged from land plants over 1 billion years ago. It is a model system for studying chloroplast-based photosynthesis, as well as the structure, assembly, and function of eukaryotic flagella (cilia), which were inherited from the common ancestor of plants and animals, but lost in land plants. We sequenced the ∼120-megabase nuclear genome of
Chlamydomonas
and performed comparative phylogenomic analyses, identifying genes encoding uncharacterized proteins that are likely associated with the function and biogenesis of chloroplasts or eukaryotic flagella. Analyses of the
Chlamydomonas
genome advance our understanding of the ancestral eukaryotic cell, reveal previously unknown genes associated with photosynthetic and flagellar functions, and establish links between ciliopathy and the composition and function of flagella.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Cited by
2312 articles.
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