Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy-Reference-Cited by-同舟云学术

Pretreatment Mitochondrial Priming Correlates with Clinical Response to Cytotoxic Chemotherapy

Published:2011-11-25 Issue:6059 Volume:334 Page:1129-1133
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Chonghaile Triona Ni¹,Sarosiek Kristopher A.¹,Vo Thanh-Trang¹²,Ryan Jeremy A.¹,Tammareddi Anupama¹,Moore Victoria Del Gaizo³,Deng Jing¹,Anderson Kenneth C.¹,Richardson Paul¹,Tai Yu-Tzu¹,Mitsiades Constantine S.¹,Matulonis Ursula A.¹,Drapkin Ronny¹⁴,Stone Richard¹,DeAngelo Daniel J.¹,McConkey David J.⁵,Sallan Stephen E.⁶,Silverman Lewis⁶,Hirsch Michelle S.⁴,Carrasco Daniel Ruben¹,Letai Anthony¹

Affiliation:

1. Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Chemistry, Elon University, 400 South O’Kelly Avenue, Elon, NC 27244, USA.

4. Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.

5. Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA.

6. Department of Pediatric Hematology/Oncology, Children’s Hospital Boston, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

Abstract

The mitochondrial state of a tumor cell prior to chemotherapy may help determine how well it responds to drug treatment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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