Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy-Reference-Cited by-同舟云学术

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

Published:2020-09-25 Issue:6511 Volume:369 Page:1603-1607
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Gu Hongjing¹^ORCID,Chen Qi¹^ORCID,Yang Guan²^ORCID,He Lei¹^ORCID,Fan Hang¹^ORCID,Deng Yong-Qiang¹^ORCID,Wang Yanxiao²,Teng Yue¹,Zhao Zhongpeng¹^ORCID,Cui Yujun¹^ORCID,Li Yuchang¹,Li Xiao-Feng¹^ORCID,Li Jiangfan¹^ORCID,Zhang Na-Na¹^ORCID,Yang Xiaolan¹^ORCID,Chen Shaolong¹,Guo Yan¹,Zhao Guangyu¹^ORCID,Wang Xiliang¹^ORCID,Luo De-Yan¹,Wang Hui¹,Yang Xiao²^ORCID,Li Yan³,Han Gencheng³,He Yuxian⁴,Zhou Xiaojun⁵,Geng Shusheng⁶,Sheng Xiaoli⁶,Jiang Shibo⁷^ORCID,Sun Shihui¹^ORCID,Qin Cheng-Feng¹^ORCID,Zhou Yusen¹^ORCID

Affiliation:

1. State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China.

2. State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing 102206, China.

3. Institute of Military Cognition and Brain Sciences, Beijing 100850, China.

4. Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

5. Laboratory Animal Center, Academy of Military Medical Sciences, Beijing 100071, China.

6. Beijing JOINN Biologics Co., Beijing 100176, China.

7. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

Abstract

Modeling SARS-CoV-2 in mice Among the research tools necessary to develop medical interventions to treat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, high on the list are informative animal models with which to study viral pathogenesis. Gu et al. developed a mouse model in which a SARS-CoV-2 strain was infectious and could cause an inflammatory response and moderate pneumonia. Adaptation of this viral strain in the mouse appeared to be dependent on a critical amino acid change, Asn 501 to Tyr (N501Y), within the receptor-binding domain of the viral spike protein. The new mouse model was used to study neutralizing antibodies and a vaccine candidate against the virus. Science , this issue p. 1603

Funder

National Natural Science Foundation of China

National Science Fund for Distinguished Young Scholars

National Science and Technology Major Project of China

Beijing Municipal Science and Technology Project

National Key Plan for Scientific Research and Development of China

Innovation Fund for Medical Sciences of the Chinese Academy of Medical Sciences.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.