Coupling Termination of Transcription to Messenger RNA Maturation in Yeast-Reference-Cited by-同舟云学术

Coupling Termination of Transcription to Messenger RNA Maturation in Yeast

Published:1998-04-10 Issue:5361 Volume:280 Page:298-301
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Birse Charles E.¹²,Minvielle-Sebastia Lionel¹²,Lee Barbara A.¹²,Keller Walter¹²,Proudfoot Nick J.¹²

Affiliation:

1. C. E. Birse, B. A. Lee, N. J. Proudfoot, Sir William Dunn School of Pathology, South Parks Road, University of Oxford, Oxford OX1 3RE, UK.

2. L. Minvielle-Sebastia and W. Keller, Department of Cell Biology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

Abstract

The direct association between messenger RNA (mRNA) 3′-end processing and the termination of transcription was established for the CYC1 gene of Saccharomyces cerevisiae . The mutation of factors involved in the initial cleavage of the primary transcript at the poly(A) site ( RNA14 , RNA15 , and PCF11 ) disrupted transcription termination at the 3′ end of the CYC1 gene. In contrast, the mutation of factors involved in the subsequent polyadenylation step ( PAP1 , FIP1 , and YTH1 ) had little effect. Thus, cleavage factors link transcription termination of RNA polymerase II with pre-mRNA 3′-end processing.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference22 articles.

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