Thermographic Selection of Effective Catalysts from an Encoded Polymer-Bound Library-Reference-Cited by-同舟云学术

Thermographic Selection of Effective Catalysts from an Encoded Polymer-Bound Library

Published:1998-04-10 Issue:5361 Volume:280 Page:267-270
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Taylor Steven J.¹,Morken James P.¹

Affiliation:

1. Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599–3290, USA.

Abstract

A general method is introduced for the rapid and simultaneous evaluation of each member of large encoded catalyst libraries for the ability to catalyze a reaction in solution. The procedure was used to select active catalysts from a library of potential polymer-bound multifunctional catalysts. From ∼7000 beads screened (3150 distinct catalysts), 23 beads were selected for catalysis of an acylation reaction. Kinetic experiments indicate that the most strongly selected beads are also the most efficient catalysts.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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