A Marine Natural Product Inhibitor of Kinesin Motors-Reference-Cited by-同舟云学术

A Marine Natural Product Inhibitor of Kinesin Motors

Published:1998-04-10 Issue:5361 Volume:280 Page:292-295
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Sakowicz Roman¹²,Berdelis Michael S.¹²,Ray Krishanu¹²,Blackburn Christine L.¹²,Hopmann Cordula¹²,Faulkner D. John¹²,Goldstein Lawrence S. B.¹²

Affiliation:

1. R. Sakowicz, M. S. Berdelis, K. Ray, L. S. B. Goldstein, Department of Pharmacology, Division of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093–0683, USA.

2. C. L. Blackburn, C. Hopmann, D. J. Faulkner, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, CA 92093–0212, USA.

Abstract

Members of the kinesin superfamily of motor proteins are essential for mitotic and meiotic spindle organization, chromosome segregation, organelle and vesicle transport, and many other processes that require microtubule-based transport. A compound, adociasulfate-2, was isolated from a marine sponge, Haliclona (also known as Adocia ) species, that inhibited kinesin activity by targeting its motor domain and mimicking the activity of the microtubule. Thus, the kinesin-microtubule interaction site could be a useful target for small molecule modulators, and adociasulfate-2 should serve as an archetype for specific inhibitors of kinesin functions.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference24 articles.

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