WUSCHEL triggers innate antiviral immunity in plant stem cells

Author:

Wu Haijun1ORCID,Qu Xiaoya1ORCID,Dong Zhicheng2ORCID,Luo Linjie1,Shao Chen1,Forner Joachim3ORCID,Lohmann Jan U.3ORCID,Su Meng1,Xu Mengchu1,Liu Xiaobin2,Zhu Lei4,Zeng Jian1,Liu Sumei1,Tian Zhaoxia1ORCID,Zhao Zhong1ORCID

Affiliation:

1. Hefei National Laboratory for Physical Sciences at the Microscale, CAS Center for Excellence in Molecular Plant Sciences, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China.

2. School of Life Sciences, Guangzhou University, Guangzhou Higher Education Mega Center, Guangzhou 510006, China.

3. Department of Stem Cell Biology, Centre for Organismal Studies, Heidelberg University, Heidelberg D-69120, Germany.

4. State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China.

Abstract

Building a safe space for stem cells The meristem, the collection of stem cells that builds plants, is resistant to viral infection. Wu et al. now show that WUSCHEL, a transcription factor that helps to sustain stem cell production in the shoot apical meristem of Arabidopsis , also protects that stem cell domain from viruses. WUSCHEL inhibited viral protein synthesis by repressing methyltransferases that regulate ribosomal RNA processing and ribosome stability. Science , this issue p. 227

Funder

Deutsche Forschungsgemeinschaft

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

China Postdoctoral Science Foundation

The Strategic Priority Research Program of the Chinese Academy of Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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