Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase-Reference-Cited by-同舟云学术

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

Published:2002-09-13 Issue:5588 Volume:297 Page:1867-1870
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Munn David H.¹²,Sharma Madhav D.¹,Lee Jeffrey R.¹³,Jhaver Kanchan G.¹,Johnson Theodore S.¹,Keskin Derin B.¹,Marshall Brendan¹,Chandler Phillip¹,Antonia Scott J.⁴,Burgess Russell⁵,Slingluff Craig L.⁶,Mellor Andrew L.¹⁵

Affiliation:

1. Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA.

2. Department of Pediatrics, Medical College of Georgia, Augusta, GA 30912, USA.

3. Veterans Affairs Medical Center, and Department of Pathology, Medical College of Georgia, Augusta, GA 30912, USA.

4. Interdisciplinary Oncology Program, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.

5. Department of Medicine, Medical College of Georgia, Augusta, GA 30912, USA.

6. Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA.

Abstract

Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell proliferation in vitro. IDO-positive APCs constituted a discrete subset identified by coexpression of the cell-surface markers CD123 and CCR6. In the dendritic cell (DC) lineage, IDO-mediated suppressor activity was present in fully mature as well as immature CD123 + DCs. IDO + DCs could also be readily detected in vivo, which suggests that these cells may represent a regulatory subset of APCs in humans.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference22 articles.

1. Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance

2. The expanding world of co-stimulation: the two-signal model revisited

3. Immunity or tolerance? That is the question for dendritic cells

4. Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

5. Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

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