Spatiotemporal coordination of stem cell commitment during epidermal homeostasis-Reference-Cited by-同舟云学术

Spatiotemporal coordination of stem cell commitment during epidermal homeostasis

Published:2016-06-17 Issue:6292 Volume:352 Page:1471-1474
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Rompolas Panteleimon¹,Mesa Kailin R.¹,Kawaguchi Kyogo²,Park Sangbum¹,Gonzalez David¹,Brown Samara¹,Boucher Jonathan¹,Klein Allon M.²,Greco Valentina¹³

Affiliation:

1. Department of Genetics, Yale School of Medicine, New Haven, CT 06510, USA.

2. Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

3. Departments of Dermatology and Cell Biology, Yale Stem Cell Center, Yale Cancer Center, Yale School of Medicine, New Haven, CT 06510, USA.

Abstract

Tracking stem cell fate in time and space After injury and during homeostasis, tissues rely on the balance of cell loss and renewal. Rompolas et al. visualized individual stem cells over their lifetime in the epidermis of live mice. Tracking stem cells over multiple generations revealed that tissue homeostasis in the mouse epidermis is not maintained by asymmetric cell division as previously thought, but through the coordination of sibling cell fate and lifetimes. Furthermore, differentiating stem cells reused the existing spatial organization of the epidermis. Science , this issue p. 1471

Funder

New York Stem Cell Foundation

Edward Mallinckrodt Jr. Foundation

National Institute of Arthritis and Musculoskeletal and Skin Disease (NIAMS)

NIH

NSF Graduate Research Fellow

New York Stem Cell Foundation-Druckenmiller Fellow

CT Stem Cell

Burroughs Wellcome Fund

Publisher

American Association for the Advancement of Science (AAAS)

Subject