History of winning remodels thalamo-PFC circuit to reinforce social dominance-Reference-Cited by-同舟云学术

History of winning remodels thalamo-PFC circuit to reinforce social dominance

Published:2017-07-14 Issue:6347 Volume:357 Page:162-168
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhou Tingting¹²³⁴^ORCID,Zhu Hong¹²³⁴,Fan Zhengxiao³⁴^ORCID,Wang Fei¹²,Chen Yang¹^ORCID,Liang Hexing³⁴,Yang Zhongfei¹,Zhang Lu⁵,Lin Longnian⁶,Zhan Yang⁷,Wang Zheng¹^ORCID,Hu Hailan³⁴⁸^ORCID

Affiliation:

1. Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, P.R. China.

2. Graduate School of Chinese Academy of Sciences, Shanghai 200031, P.R. China.

3. Interdisciplinary Institute of Neuroscience and Technology, Qiushi Academy for Advanced Studies, Zhejiang University, Hangzhou 310012, P.R. China.

4. Center for Neuroscience, Key Laboratory of Medical Neurobiology of the Ministry of Health of China, School of Medicine, Zhejiang University, Hangzhou 310058, P.R. China.

5. Shanghai Center for Mathematical Sciences, Fudan University, Shanghai 200433, P.R. China.

6. Key Laboratory of Brain Functional Genomics, East China Normal University, Shanghai 200062, P.R. China.

7. Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P.R. China.

8. Mental Health Center, School of Medicine, Zhejiang University, Hangzhou 310013, P.R. China.

Abstract

The brain circuits of a winner Social dominance in mice depends on their history of winning in social contests. Zhou et al. found that this effect is mediated by neuronal projections from the thalamus to a brain region called the dorsomedial prefrontal cortex. Selective manipulation of synapses driven by this input revealed a causal relationship between circuit activity and mental effort–based dominance behavior. Thus, synapses in this pathway store the memory of previous winning or losing history. Science , this issue p. 162

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of China

Strategic Priority Research Program (B) of the Chinese Academy of Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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