The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury-Reference-Cited by-同舟云学术

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

Published:2016-11-11 Issue:6313 Volume:354 Page:765-768
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hu Bo¹,Jin Chengcheng¹,Li Hua-Bing¹,Tong Jiyu¹²,Ouyang Xinshou³,Cetinbas Naniye Malli⁴,Zhu Shu¹,Strowig Till¹,Lam Fred C.⁴,Zhao Chen⁵,Henao-Mejia Jorge¹,Yilmaz Omer⁴,Fitzgerald Katherine A.⁶,Eisenbarth Stephanie C.¹⁷,Elinav Eran¹,Flavell Richard A.¹⁸

Affiliation:

1. Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

2. Biomedical Translational Research Institute, Jinan University, Guangzhou 510632, China.

3. Section of Digestive Diseases, Yale University, New Haven, CT 06520, USA.

4. Koch Institute for Integrative Cancer Biology, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA.

5. Hematology Oncology Fellowship Program, National Institutes of Health, Bethesda, MD 20892, USA.

6. Division of Infectious Diseases and Immunology, Program in Innate Immunity, University of Massachusetts Medical School, Worcester, MA 01605, USA.

7. Department of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

8. Howard Hughes Medical Institute, Chevy Chase, MD 20815-6789, USA.

Abstract

AIMing to block tissue damage Ionizing radiation kills actively dividing cells such as those in the gut and in the bone marrow. Hu et al. found a pathological role for the protein AIM2 in irradiation-induced tissue damage. AIM2 is best known for its role in sensing double-stranded DNA in the cytoplasm and alerting the body to infections. It seems that AIM2 also senses DNA damage caused by radiation and then triggers intestinal epithelial cells and bone marrow cells to die. Deficiency in AIM2 protected mice from irradiation-induced gastrointestinal syndrome and hematopoietic failure. Science , this issue p. 765

Funder

NIH

Howard Hughes Medical Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. Major Radiation Exposure — What to Expect and How to Respond

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3. p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis

4. Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

5. Mechanisms and Functions of Inflammasomes

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