Human Sperm Binding Is Mediated by the Sialyl-Lewis x Oligosaccharide on the Zona Pellucida-Reference-Cited by-同舟云学术

Human Sperm Binding Is Mediated by the Sialyl-Lewis x Oligosaccharide on the Zona Pellucida

Published:2011-09-23 Issue:6050 Volume:333 Page:1761-1764
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pang Poh-Choo¹,Chiu Philip C. N.²,Lee Cheuk-Lun²,Chang Lan-Yi³,Panico Maria¹,Morris Howard R.¹,Haslam Stuart M.¹,Khoo Kay-Hooi³,Clark Gary F.⁴,Yeung William S. B.²,Dell Anne¹

Affiliation:

1. Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London SW7 2AZ, UK.

2. Department of Obstetrics and Gynaecology, Centre for Reproduction, Development and Growth, University of Hong Kong, Pokfulam Road, Hong Kong, China.

3. Institute of Biological Chemistry, Academia Sinica, Taipei, 11529, Taiwan.

4. Department of Obstetrics, Gynecology, and Women’s Health, School of Medicine, University of Missouri, Columbia, MO 65212, USA.

Abstract

Fertilization in humans is initiated by binding of spermatozoa to a selectin ligand on the egg’s extracellular matrix.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference35 articles.

1. Glycobiology of sperm-egg interactions in deuterostomes

2. A profile of fertilization in mammals

3. Evidence suggesting that L-fucose is part of a recognition signal for sperm-zona pellucida attachment in mammals