Binding of Hepatitis C Virus to CD81-Reference-Cited by-同舟云学术

Binding of Hepatitis C Virus to CD81

Published:1998-10-30 Issue:5390 Volume:282 Page:938-941
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Pileri Piero¹,Uematsu Yasushi¹,Campagnoli Susanna¹,Galli Giuliano¹,Falugi Fabiana¹,Petracca Roberto¹,Weiner Amy J.¹,Houghton Michael¹,Rosa Domenico¹,Grandi Guido¹,Abrignani Sergio¹

Affiliation:

1. P. Pileri, Y. Uematsu, S. Campagnoli, G. Galli, F. Falugi, R. Petracca, D. Rosa, G. Grandi, S. Abrignani, IRIS, Chiron, Siena 53100, Italy. A. J. Weiner and M. Houghton, Chiron Corporation, Emeryville, CA 94608, USA.

Abstract

Chronic hepatitis C virus (HCV) infection occurs in about 3 percent of the world's population and is a major cause of liver disease. HCV infection is also associated with cryoglobulinemia, a B lymphocyte proliferative disorder. Virus tropism is controversial, and the mechanisms of cell entry remain unknown. The HCV envelope protein E2 binds human CD81, a tetraspanin expressed on various cell types including hepatocytes and B lymphocytes. Binding of E2 was mapped to the major extracellular loop of CD81. Recombinant molecules containing this loop bound HCV and antibodies that neutralize HCV infection in vivo inhibited virus binding to CD81 in vitro.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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4. Cryoglobulinemia is a B lymphocyte proliferative disorder characterized by the presence of cryoglobulins (immunoglobulins insoluble at 4°C) in the serum. The disease is often associated with multiple organ involvement and is due to the deposition of immune complexes in small blood vessels. Three types of cryoglobulinemia can be distinguished. Type I is formed by monoclonal immunoglobulin M (IgM) and is also known as Waldenstrom's disease. Type II is formed by IgM-IgG complexes in the serum; the IgG fraction is polyclonal whereas the IgM fraction is monoclonal with rheumatoid factor activity. Type III is formed by polyclonal immunoglobulins. More than 80% of the patients with type II and type III cryoglobulinemia are infected by HCV often without liver disease [

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