Affiliation:
1. Department of Bioengineering, Y2E2-269B, 473 Via Ortega, Stanford, CA 94305–4201, USA.
Abstract
Biological Transistor
A transistor is a device that amplifies and switches electronic signals.
Bonnet
et al.
(p.
599
, published online 28 March; see the Perspective by
Benenson
) engineered a genetic circuit to behave like a transistor in individual living cells. Instead of regulating messenger RNA levels, which has been used previously in designing such systems, the approach relied on changing the state of double-stranded DNA. Six basic logic gates were designed and constructed that were based on the activity of two serine recombinases.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
429 articles.
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