Differences in Left-Right Axis Pathways in Mouse and Chick: Functions of FGF8 and SHH-Reference-Cited by-同舟云学术

Differences in Left-Right Axis Pathways in Mouse and Chick: Functions of FGF8 and SHH

Published:1999-07-16 Issue:5426 Volume:285 Page:403-406
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Meyers Erik N.¹²,Martin Gail R.¹

Affiliation:

1. Department of Anatomy and Program in Developmental Biology, School of Medicine, and

2. Department of Pediatrics, School of Medicine, University of California at San Francisco, San Francisco, CA 94143, USA.

Abstract

A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that the Fgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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