Optical control of cell signaling by single-chain photoswitchable kinases-Reference-Cited by-同舟云学术

Optical control of cell signaling by single-chain photoswitchable kinases

Published:2017-02-24 Issue:6327 Volume:355 Page:836-842
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhou Xin X.¹^ORCID,Fan Linlin Z.¹,Li Pengpeng²,Shen Kang²,Lin Michael Z.¹³^ORCID

Affiliation:

1. Department of Bioengineering, Stanford University, Stanford, CA, USA.

2. Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA, USA.

3. Department of Neurobiology, Stanford University, Stanford, CA, USA.

Abstract

Shining a light on cell signaling Protein kinases are proteins that are used to transmit signals within cells. Zhou et al. engineered diverse kinases so that they could be switched on and off with visible light. They modified the fluorescent protein Dronpa so that instead of being tetrameric, it dimerized in violet light and dissociated in cyan light, and they fused two copies to representatives from different families of kinases. The engineered kinases could be photo-switched with spatial and temporal precision and were successfully used to study a variety of signaling pathways. Science , this issue p. 836

Funder

Howard Hughes Medical Institute

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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