Nuclear Actin Network Assembly by Formins Regulates the SRF Coactivator MAL

Abstract

Nuclear Actin in Action Actin polymerization is essential for structures in mammalian cells. Although actin filament network structures are observed in the cytoplasm and at the plasma membrane, monomeric actin is also seen in the nucleus. Baarlink et al. (p. 864 , published online 4 April) directly visualized a distinct and dynamic actin network within the nucleus in living cells. The network spanned the entire nucleus and appeared to be enriched along the nuclear cortex. Transient formation of a nuclear actin network may be induced by the transcriptional serum response.