Comment on “Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence”

Author:

Sherman David H.1,Tsukamoto Sachiko2,Williams Robert M.34

Affiliation:

1. Life Sciences Institute and Departments of Medicinal Chemistry, Microbiology and Immunology, and Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.

2. Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.

3. Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.

4. The University of Colorado Cancer Center, Aurora, CO 80045, USA.

Abstract

Ma et al . (Reports, 10 October 2014, p. 219) report asymmetric syntheses of sceptrin and massadine and, through a stereochemical reassignment, claim to “uncover enantiodivergence as a new biosynthetic paradigm for natural products.” We challenge and clarify this claim with relevant examples from the literature of this well-known phenomenon of enantiodivergent congener biosynthesis within the same producing organism.

Funder

National Institutes of Health

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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