Affiliation:
1. Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA.
Abstract
Although in
Saccharomyces cerevisiae
the initiation of meiotic recombination, as indicated by double-strand break formation, appears to be functionally linked to the initiation of synapsis, meiotic chromosome synapsis in
Drosophila
females occurs in the absence of meiotic exchange. Electron microscopy of oocytes from females homozygous for either of two meiotic mutants (
mei-W68
and
mei-P22
), which eliminate both meiotic crossing over and gene conversion, revealed normal synaptonemal complex formation. Thus, synapsis in
Drosophila
is independent of meiotic recombination, consistent with a model in which synapsis is required for the initiation of meiotic recombination. Furthermore, the basic processes of early meiosis may have different functional or temporal relations, or both, in yeast and
Drosophila
.
Publisher
American Association for the Advancement of Science (AAAS)
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