The human tumor microbiome is composed of tumor type–specific intracellular bacteria-Reference-Cited by-同舟云学术

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

Published:2020-05-29 Issue:6494 Volume:368 Page:973-980
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Nejman Deborah¹^ORCID,Livyatan Ilana¹²^ORCID,Fuks Garold³^ORCID,Gavert Nancy¹^ORCID,Zwang Yaara¹^ORCID,Geller Leore T.¹^ORCID,Rotter-Maskowitz Aviva¹^ORCID,Weiser Roi⁴⁵^ORCID,Mallel Giuseppe¹^ORCID,Gigi Elinor¹,Meltser Arnon¹^ORCID,Douglas Gavin M.⁶^ORCID,Kamer Iris⁷^ORCID,Gopalakrishnan Vancheswaran⁸^ORCID,Dadosh Tali⁹,Levin-Zaidman Smadar⁹^ORCID,Avnet Sofia¹⁰^ORCID,Atlan Tehila¹¹^ORCID,Cooper Zachary A.¹²^ORCID,Arora Reetakshi⁸,Cogdill Alexandria P.¹³^ORCID,Khan Md Abdul Wadud⁸^ORCID,Ologun Gabriel⁸^ORCID,Bussi Yuval¹²¹⁴^ORCID,Weinberger Adina¹²^ORCID,Lotan-Pompan Maya¹²^ORCID,Golani Ofra¹⁵^ORCID,Perry Gili¹⁶^ORCID,Rokah Merav¹⁷^ORCID,Bahar-Shany Keren¹⁶,Rozeman Elisa A.¹⁸,Blank Christian U.¹⁸,Ronai Anat¹⁹,Shaoul Ron¹⁹,Amit Amnon²⁰²¹^ORCID,Dorfman Tatiana²²²³,Kremer Ran²⁴,Cohen Zvi R.⁵²⁵,Harnof Sagi⁵²⁶^ORCID,Siegal Tali²⁷,Yehuda-Shnaidman Einav²⁸,Gal-Yam Einav Nili²⁹,Shapira Hagit²⁸,Baldini Nicola¹⁰³⁰^ORCID,Langille Morgan G. I.⁶³¹^ORCID,Ben-Nun Alon⁵¹⁷,Kaufman Bella⁵⁷,Nissan Aviram³²,Golan Talia⁵⁷,Dadiani Maya¹⁶^ORCID,Levanon Keren⁵¹⁶^ORCID,Bar Jair⁵⁷^ORCID,Yust-Katz Shlomit⁵²⁷^ORCID,Barshack Iris⁵³³,Peeper Daniel S.³⁴,Raz Dan J.³⁵,Segal Eran¹²^ORCID,Wargo Jennifer A.⁸¹³^ORCID,Sandbank Judith²⁸^ORCID,Shental Noam³⁶^ORCID,Straussman Ravid¹^ORCID

Affiliation:

1. Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

2. Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot, Israel.

3. Department of Physics of Complex Systems, Weizmann Institute of Science, Rehovot, Israel.

4. Division of Surgery, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel.

5. Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

6. Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada.

7. Institute of Oncology, Sheba Medical Center, Ramat Gan, Israel.

8. Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

9. Department of Chemical Research Support, Weizmann Institute of Science, Rehovot, Israel.

10. Orthopaedic Pathophysiology and Regenerative Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

11. Department of Bioinformatics, Jerusalem College of Technology, Jerusalem, Israel.

12. Translational Medicine, Oncology R&D, AstraZeneca, Gaithersburg, MD, USA.

13. Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

14. Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel.

15. Department of Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel.

16. Cancer Research Center, Sheba Medical Center, Ramat Gan, Israel.

17. Department of Thoracic Surgery, Sheba Medical Center, Ramat Gan, Israel.

18. Department of Medical Oncology and Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.

19. Pediatric Gastroenterology Institute, Rambam Medical Center, Haifa, Israel.

20. Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

21. Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.

22. Division of General Surgery, Rambam Health Care Campus, Haifa, Israel.

23. Ambulatory and Breast Surgery Service, Rambam Health Care Campus, Haifa, Israel.

24. Department of Thoracic Surgery, Rambam Health Care Campus, Haifa, Israel.

25. Department of Neurosurgery, Sheba Medical Center, Ramat Gan, Israel.

26. Department of Neurosurgery, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.

27. Neuro-Oncology Unit, Rabin Medical Center, Beilinson Hospital, Petach Tikva, Israel.

28. Institute of Pathology, Megalab, Maccabi Healthcare Services, Rehovot, Israel.

29. Breast Oncology Institute, Sheba Medical Center, Ramat Gan, Israel.

30. Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

31. Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.

32. Department of Surgical Oncology (Surgery C), Sheba Medical Center, Ramat Gan, Israel.

33. Department of Pathology, Sheba Medical Center, Ramat Gan, Israel.

34. Division of Molecular Oncology & Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands.

35. Division of Thoracic Surgery, City of Hope Medical Center, Duarte, CA, USA.

36. Department of Mathematics and Computer Science, The Open University of Israel, Ra’anana, Israel.

Abstract

Profiling tumor bacteria Bacteria are well-known residents in human tumors, but whether their presence is advantageous to the tumors or to the bacteria themselves has been unclear. As an initial step toward addressing this question, Nejman et al. produced an exhaustive catalog of the bacteria present in more than 1500 human tumors representing seven different tumor types (see the Perspective by Atreya and Turnbaugh). They found that the bacteria within tumors were localized within both cancer cells and immune cells and that the bacterial composition varied according to tumor type. Certain biologically plausible associations were identified. For example, breast cancer subtypes characterized by increased oxidative stress were enriched in bacteria that produce mycothiol, which can detoxify reactive oxygen species. Science , this issue p. 973 ; see also p. 938

Funder

National Institutes of Health

American Association for Cancer Research

Israel Cancer Research Fund

H2020 European Research Council

United States-Israel Binational Science Foundation

Israel Ministry of Science, Technology & Space

Israel Science Foundation

Rising Tide Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject