Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila-Reference-Cited by-同舟云学术

Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila

Published:2010-12-24 Issue:6012 Volume:330 Page:1824-1827
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Janic Ana¹,Mendizabal Leire¹,Llamazares Salud¹,Rossell David²,Gonzalez Cayetano¹³

Affiliation:

1. Cell Division Group, Institute for Research in Biomedicine (IRB-Barcelona), PCB, c/Baldiri Reixac 10-12, Barcelona, Spain.

2. Bioinformatics and Biostatistics Unit, IRB-Barcelona, PCB, c/Baldiri Reixac 10-12, Barcelona, Spain.

3. Institució Catalana de Recerca i Estudis Avançats (ICREA), Passeig Lluís Companys 23, Barcelona, Spain.

Abstract

Curing Insect Brain Tumors Mammalian tumors often show ectopic expression of genes that normally function only in the germ line. The possible contribution of cancer germline (CG) genes to malignancy is unknown. Janic et al. (p. 1824 ; see the Perspective by Wu and Ruvkun ) found that CG genes are also expressed in Drosophila brain tumors caused by mutants in the gene lethal (3) malignant brain tumor . Moreover, inactivation of some of these genes suppressed fly tumor growth. Because some Drosophila CG genes are orthologs of human CG genes, it is possible that inactivation of germline genes may show human tumor suppressor activity.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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