Stable inhibitory activity of regulatory T cells requires the transcription factor Helios-Reference-Cited by-同舟云学术

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

Published:2015-10-16 Issue:6258 Volume:350 Page:334-339
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kim Hye-Jung¹²,Barnitz R. Anthony³⁴,Kreslavsky Taras¹²,Brown Flavian D.³,Moffett Howell¹,Lemieux Madeleine E.⁵,Kaygusuz Yasemin¹,Meissner Torsten¹²,Holderried Tobias A. W.¹²,Chan Susan⁶⁷,Kastner Philippe⁶⁷,Haining W. Nicholas³⁴⁸,Cantor Harvey¹²

Affiliation:

1. Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

2. Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston MA.

3. Department of Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA.

4. Department of Pediatrics, Boston Children’s Hospital, Boston, MA, USA.

5. Bioinfo, Plantagenet, Canada.

6. Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U964, CNRS UMR 7104, Université de Strasbourg, 67404 Illkirch, France.

7. Faculté de Médecine, Université de Strasbourg, Strasbourg, France.

8. Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Abstract

How T cells maintain their identity Although best known for their pathogen-fighting prowess, T lymphocytes also ensure that the immune response does not run amok. A subset of T cells called regulatory T cells (T regs ) performs this function by, for example, making sure T cells only attack pathogens and not self. T cells can exhibit plasticity in their functions in the face of an inflammatory stimulus. Kim et al. sought to identify the molecules that ensure the stable maintenance of T regs . Using genetically modified mice, they found that both CD4 + and CD8 + T regs require the transcription factor Helios to stably maintain their identity. Science , this issue p. 334

Funder

NIH

Arthritis National Research Foundation

LeRoy Schecter Research Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.

1. Stability of the Regulatory T Cell Lineage in Vivo

2. Plasticity of Foxp3+ T Cells Reflects Promiscuous Foxp3 Expression in Conventional T Cells but Not Reprogramming of Regulatory T Cells

3. Inhibition of follicular T-helper cells by CD8+ regulatory T cells is essential for self tolerance