Dermal sheath contraction powers stem cell niche relocation during hair cycle regression-Reference-Cited by-同舟云学术

Dermal sheath contraction powers stem cell niche relocation during hair cycle regression

Published:2020-01-10 Issue:6474 Volume:367 Page:161-166
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Heitman Nicholas¹²³^ORCID,Sennett Rachel¹²³,Mok Ka-Wai¹²,Saxena Nivedita¹²³^ORCID,Srivastava Devika¹²,Martino Pieter¹²,Grisanti Laura¹²^ORCID,Wang Zichen⁴^ORCID,Ma’ayan Avi⁴^ORCID,Rompolas Panteleimon⁵,Rendl Michael¹²⁶^ORCID

Affiliation:

1. Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

2. Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

3. Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

4. Department of Pharmacological Sciences, Mount Sinai Center for Bioinformatics, BD2K-LINCS Data Coordination and Integration Center, Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG), Icahn School of Medicine at Mount Sinai, New York, NY, USA.

5. Department of Dermatology, Institute for Regenerative Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

6. Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Abstract

Niche relocated by muscle contraction Regulation of adult stem cells by their microenvironment, or niche, is essential for tissue homeostasis and for regeneration after injury and during aging. Normal regression of hair follicles during the hair cycle poses a particular challenge for maintaining a functional proximity of stem cells to their niche, especially the specialized mesenchymal cells of the dermal papilla. Using mice as a model organism, Heitman et al. demonstrate that the follicle dermal sheath is an active smooth muscle that drives tissue remodeling through coordinated cell contraction, enabling renewed contact between the dermal papilla and hair follicle stem cells during hair follicle regression. This biomechanical mechanism of niche relocation may be utilized in other stem cell niche systems. Science , this issue p. 161

Funder

NIH Office of the Director

National Eye Institute

National Institute of General Medical Sciences

National Institute of Arthritis and Musculoskeletal and Skin Diseases

New York State Stem Cell Science

National Institute of Dental and Craniofacial Research

Dermatology Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary