UDP-GlcNAc 2-Epimerase: A Regulator of Cell Surface Sialylation-Reference-Cited by-同舟云学术

UDP-GlcNAc 2-Epimerase: A Regulator of Cell Surface Sialylation

Published:1999-05-21 Issue:5418 Volume:284 Page:1372-1376
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Keppler Oliver T.¹,Hinderlich Stephan²,Langner Josmar¹,Schwartz-Albiez Reinhard³,Reutter Werner²,Pawlita Michael¹

Affiliation:

1. Applied Tumor Virology Program,

2. Institut für Molekularbiologie und Biochemie, Freie Universität Berlin, Arnimallee 22, D-14195 Berlin-Dahlem, Germany.

3. Tumor Immunology Program, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.

Abstract

Modification of cell surface molecules with sialic acid is crucial for their function in many biological processes, including cell adhesion and signal transduction. Uridine diphosphate- N -acetylglucosamine 2-epimerase (UDP-GlcNAc 2-epimerase) is an enzyme that catalyzes an early, rate-limiting step in the sialic acid biosynthetic pathway. UDP-GlcNAc 2-epimerase was found to be a major determinant of cell surface sialylation in human hematopoietic cell lines and a critical regulator of the function of specific cell surface adhesion molecules.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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