Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors-Reference-Cited by-同舟云学术

Vascular and Neurogenic Rejuvenation of the Aging Mouse Brain by Young Systemic Factors

Published:2014-05-09 Issue:6184 Volume:344 Page:630-634
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Katsimpardi Lida¹²,Litterman Nadia K.¹²,Schein Pamela A.¹²,Miller Christine M.¹²³,Loffredo Francesco S.¹²⁴,Wojtkiewicz Gregory R.⁵,Chen John W.⁵,Lee Richard T.¹²⁴,Wagers Amy J.¹²³,Rubin Lee L.¹²

Affiliation:

1. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

2. Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

3. Howard Hughes Medical Institute, Joslin Diabetes Center and the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA.

4. Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA.

5. Center for Systems Biology and Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Help the Aged Muscle function declines with age, as does neurogenesis in certain brain regions. Two teams analyzed the effects of heterochronic parabiosis in mice. Sinha et al. (p. 649 ) found that when an aged mouse shares a circulatory system with a youthful mouse, the aged mouse sees improved muscle function, and Katsimpardi et al. (p. 630 ) observed increased generation of olfactory neurons. In both cases, Growth Differentiation Factor 11 appeared to be one of the key components of the young blood.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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