Structure of Complement Receptor 2 in Complex with Its C3d Ligand-Reference-Cited by-同舟云学术

Structure of Complement Receptor 2 in Complex with Its C3d Ligand

Published:2001-06 Issue:5522 Volume:292 Page:1725-1728
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Szakonyi Gerda¹,Guthridge Joel M.²,Li Dawei¹,Young Kendra²,Holers V. Michael²,Chen Xiaojiang S.¹

Affiliation:

1. Department of Biochemistry and Molecular Genetics,

2. Departments of Medicine and Immunology, University of Colorado Health Science Center, School of Medicine, Denver, CO 80262, USA.

Abstract

Complement receptor 2 (CR2/CD21) is an important receptor that amplifies B lymphocyte activation by bridging the innate and adaptive immune systems. CR2 ligands include complement C3d and Epstein-Barr virus glycoprotein 350/220. We describe the x-ray structure of this CR2 domain in complex with C3d at 2.0 angstroms. The structure reveals extensive main chain interactions between C3d and only one short consensus repeat (SCR) of CR2 and substantial SCR side-side packing. These results provide a detailed understanding of receptor-ligand interactions in this protein family and reveal potential target sites for molecular drug design.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference33 articles.

1. Fearon D. T., Semin. Immunol. 10, 355 (1998).

2. S. K. A. Law K. B. M. Reid Complement in Focus Series D. Male Ed. (IRL Press Oxford UK ed. 2 1995).

3. Carter R. H., Fearon D. T., Science 256, 105 (1992).

4. Moir S., et al., J. Exp. Med. 192, 637 (2000).

5. Aubry J. P., Pochon S., Graber P., Jansen K. U., Bonnefoy J. Y., Nature 358, 505 (1992).

Cited by 146 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Deciphering ACE2-RBD binding affinity through peptide scanning: A molecular dynamics simulation approach;Computers in Biology and Medicine;2024-05

2. Structural biology of complement receptors;Frontiers in Immunology;2023-09-11

3. IgE, IgE Receptors and Anti-IgE Biologics: Protein Structures and Mechanisms of Action;Annual Review of Immunology;2023-04-26

4. A high-level programming language for generative protein design;2022-12-22

5. Quantifying In Situ Structural Stabilities of Human Blood Plasma Proteins Using a Novel Iodination Protein Stability Assay;Journal of Proteome Research;2022-11-10