Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses-Reference-Cited by-同舟云学术

Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses

Published:1999-10-08 Issue:5438 Volume:286 Page:300-303
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Uchida Junji¹,Yasui Teruhito¹,Takaoka-Shichijo Yuko¹,Muraoka Masaaki¹,Kulwichit Wanla²,Raab-Traub Nancy²,Kikutani Hitoshi¹

Affiliation:

1. Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan.

2. Line-berger Comprehensive Cancer Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.

Abstract

The effect of the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) on the activation and differentiation of normal B cells was investigated. B cells of transgenic mice expressing LMP1 under the control of immunoglobulin promoter/enhancer displayed enhanced expression of activation antigens and spontaneously proliferated and produced antibody. Humoral immune responses of LMP1 transgenic mice in CD40-deficient or normal backgrounds revealed that LMP1 mimics CD40 signals to induce extrafollicular B cell differentiation but, unlike CD40, blocks germinal center formation. Thus, these specific properties of LMP1 may determine the site of primary B cell infection and the state of infection in the natural course of EBV infection, whereas subsequent loss of LMP1 expression may affect the site of persistent latent infection.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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