Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy-Reference-Cited by-同舟云学术

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Published:2011-01-28 Issue:6016 Volume:331 Page:456-461
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Egan Daniel F.¹,Shackelford David B.¹,Mihaylova Maria M.¹²,Gelino Sara³,Kohnz Rebecca A.¹,Mair William¹,Vasquez Debbie S.¹,Joshi Aashish⁴,Gwinn Dana M.¹,Taylor Rebecca¹,Asara John M.⁵,Fitzpatrick James⁶,Dillin Andrew¹²,Viollet Benoit⁷,Kundu Mondira⁴,Hansen Malene³,Shaw Reuben J.¹²

Affiliation:

1. Molecular and Cell Biology Laboratory, Dulbecco Center for Cancer Research, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

2. Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

3. Graduate School of Biomedical Sciences, Del E. Webb Neuroscience, Aging and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.

4. Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105, USA.

5. Division of Signal Transduction, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.

6. Waitt Advanced Biophotonics Center, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

7. Inserm, U1016, Institut Cochin, Université Paris Descartes, CNRS (UMR 8104), Paris, France.

Abstract

A protein kinase links energy stores to control of autophagy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference32 articles.

1. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

2. The LKB1–AMPK pathway: metabolism and growth control in tumour suppression

3. The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

4. Regulation Mechanisms and Signaling Pathways of Autophagy

5. The role of the Atg1/ULK1 complex in autophagy regulation

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