Role of Yersinia Murine Toxin in Survival of Yersinia pestis in the Midgut of the Flea Vector-Reference-Cited by-同舟云学术

Role of Yersinia Murine Toxin in Survival of Yersinia pestis in the Midgut of the Flea Vector

Published:2002-04-26 Issue:5568 Volume:296 Page:733-735
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Hinnebusch B. Joseph¹,Rudolph Amy E.²,Cherepanov Peter³,Dixon Jack E.²,Schwan Tom G.¹,Forsberg Åke³

Affiliation:

1. Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA.

2. Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109, USA.

3. Department of Medical Countermeasures, Swedish Defense Research Agency, S-901 82 Umeå, and Department of Molecular Biology, Umeå University, S-901 87 Umeå, Sweden.

Abstract

Transmission by flea bite is a relatively recent adaptation that distinguishes Yersinia pestis , the plague bacillus, from closely related enteric bacteria. Here, a plasmid-encoded phospholipase D (PLD), previously characterized as Yersinia murine toxin (Ymt), was shown to be required for survival of Y. pestis in the midgut of its principal vector, the rat flea Xenopsylla cheopis . Intracellular PLD activity appeared to protect Y. pestis from a cytotoxic digestion product of blood plasma in the flea gut. By enabling colonization of the flea midgut, acquisition of this PLD may have precipitated the transition of Y. pestis to obligate arthropod-borne transmission.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference30 articles.

1. M. Achtman et al. Proc. Natl. Acad. Sci. U.S.A. 96 14043 (1999).

2. Brubaker R. R., Clin. Microbiol. Rev. 4, 309 (1991).

3. P. A. Cherepanov et al. Mol. Gen. Mikrobiol. Virusol. 12 19 (1991).

4. P. Hu et al. J. Bacteriol. 180 5192 (1998).

5. Lindler L. E., Plano G. V., Burland V., Mayhew G. F., Blattner F. R., Infect. Immun. 66, 5731 (1998).

Cited by 259 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Progress on the research and development of plague vaccines with a call to action;npj Vaccines;2024-09-07

2. Transovarial transmission of Yersinia pestis in its flea vector Xenopsylla cheopis;Nature Communications;2024-08-23

3. A protein O-GlcNAc glycosyltransferase regulates the antioxidative response in Yersinia pestis;Nature Communications;2024-08-16

4. Unveiling the dance of evolution: Pla-mediated cleavage of Ymt modulates the virulence dynamics of Yersinia pestis;mBio;2024-08-14

5. Role of the Yersinia pestis phospholipase D (Ymt) in the initial aggregation step of biofilm formation in the flea;mBio;2024-06-12