Structure and dynamics of the active human parathyroid hormone receptor-1-Reference-Cited by-同舟云学术

Structure and dynamics of the active human parathyroid hormone receptor-1

Published:2019-04-12 Issue:6436 Volume:364 Page:148-153
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Zhao Li-Hua¹^ORCID,Ma Shanshan¹²^ORCID,Sutkeviciute Ieva³^ORCID,Shen Dan-Dan⁴^ORCID,Zhou X. Edward⁵^ORCID,de Waal Parker W.⁵^ORCID,Li Chen-Yao¹²^ORCID,Kang Yanyong¹,Clark Lisa J.³⁶^ORCID,Jean-Alphonse Frederic G.³^ORCID,White Alex D.³⁷^ORCID,Yang Dehua¹^ORCID,Dai Antao¹^ORCID,Cai Xiaoqing¹^ORCID,Chen Jian⁸^ORCID,Li Cong⁸^ORCID,Jiang Yi¹^ORCID,Watanabe Tomoyuki⁹,Gardella Thomas J.⁹,Melcher Karsten⁵^ORCID,Wang Ming-Wei¹⁸^ORCID,Vilardaga Jean-Pierre³^ORCID,Xu H. Eric¹⁵^ORCID,Zhang Yan⁴^ORCID

Affiliation:

1. The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

2. University of Chinese Academy of Sciences, Beijing 100049, China.

3. Laboratory for GPCR Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

4. Department of Pathology of Sir Run Run Shaw Hospital and Department of Biophysics, Zhejiang University School of Medicine, Hangzhou 310058, China.

5. Center for Cancer and Cell Biology, Innovation and Integration Program, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

6. Graduate Program in Molecular Biophysics and Structural Biology, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

7. Graduate Program in Molecular Pharmacology, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA.

8. School of Pharmacy, Fudan University, Shanghai 201203, China.

9. Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Abstract

Bone-cell regulation, fleshed out One of many medically relevant G protein–coupled receptors, parathyroid hormone receptor-1 (PTH1R) functions in the control of calcium homeostasis and bone physiology. Zhao et al. used cryo–election microscopy to observe the structure of PTH1R in a complex with a modified form of parathyroid hormone and stimulatory G protein. The structural model helps explain how parathyroid hormone interacts with its receptor and the molecular basis for receptor activation. Science , this issue p. 148

Funder

National Institutes of Health

Foundation for the National Institutes of Health

Van Andel Research Institute

Natural Science Foundation of Shanghai

the National Natural Science Foundation of China

the Jay and Betty Van Andel Foundation

the Fudan-SIMM Joint Research Fund

SA-SIBS Scholarship Program

the Youth Innovation Promotion Association

Publisher

American Association for the Advancement of Science (AAAS)