Effects of microbiota-directed foods in gnotobiotic animals and undernourished children
Author:
Gehrig Jeanette L.ORCID, Venkatesh Siddarth, Chang Hao-WeiORCID, Hibberd Matthew C.ORCID, Kung Vanderlene L.ORCID, Cheng JiyeORCID, Chen Robert Y.ORCID, Subramanian Sathish, Cowardin Carrie A.ORCID, Meier Martin F., O’Donnell DavidORCID, Talcott MichaelORCID, Spears Larry D.ORCID, Semenkovich Clay F.ORCID, Henrissat BernardORCID, Giannone Richard J.ORCID, Hettich Robert L.ORCID, Ilkayeva Olga, Muehlbauer MichaelORCID, Newgard Christopher B., Sawyer ChristopherORCID, Head Richard D., Rodionov Dmitry A.ORCID, Arzamasov Aleksandr A.ORCID, Leyn Semen A.ORCID, Osterman Andrei L.ORCID, Hossain Md Iqbal, Islam Munirul, Choudhury Nuzhat, Sarker Shafiqul Alam, Huq Sayeeda, Mahmud Imteaz, Mostafa Ishita, Mahfuz MustafaORCID, Barratt Michael J.ORCID, Ahmed Tahmeed, Gordon Jeffrey I.ORCID
Abstract
To examine the contributions of impaired gut microbial community development to childhood undernutrition, we combined metabolomic and proteomic analyses of plasma samples with metagenomic analyses of fecal samples to characterize the biological state of Bangladeshi children with severe acute malnutrition (SAM) as they transitioned, after standard treatment, to moderate acute malnutrition (MAM) with persistent microbiota immaturity. Host and microbial effects of microbiota-directed complementary food (MDCF) prototypes targeting weaning-phase bacterial taxa underrepresented in SAM and MAM microbiota were characterized in gnotobiotic mice and gnotobiotic piglets colonized with age- and growth-discriminatory bacteria. A randomized, double-blind controlled feeding study identified a lead MDCF that changes the abundances of targeted bacteria and increases plasma biomarkers and mediators of growth, bone formation, neurodevelopment, and immune function in children with MAM.
Funder
National Institutes of Health Bill and Melinda Gates Foundation
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Reference124 articles.
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