Affiliation:
1. Molecular Medicine Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co., Ltd., 21 Miyukigaoka, Tsukuba, Ibaraki 305–8585, Japan.
Abstract
We characterized an activation mechanism of the human LTRPC2 protein, a member of the transient receptor potential family of ion channels, and demonstrated that LTRPC2 mediates Ca
2+
influx into immunocytes. Intracellular pyrimidine nucleotides, adenosine 5′-diphosphoribose (ADPR), and nicotinamide adenine dinucleotide (NAD), directly activated LTRPC2, which functioned as a Ca
2+
-permeable nonselective cation channel and enabled Ca
2+
influx into cells. This activation was suppressed by intracellular adenosine triphosphate. These results reveal that ADPR and NAD act as intracellular messengers and may have an important role in Ca
2+
influx by activating LTRPC2 in immunocytes.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
398 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献