Affiliation:
1. Department of Integrative Biology, University of California, Berkeley, Berkeley, CA 94720, USA.
Abstract
Getting the Dosage Right
As sex chromosomes evolve, they must compensate for differential gene dosage, especially in non-sex-specific genes. However, owing to the relative rarity of chromosomes that are in the process of becoming sex chromosomes, the ongoing evolutionary processes resulting in dosage compensation are unclear.
Ellison and Bachtrog
(p.
846
; see the Perspective by
Chuong and Feschotte
) identified a specific transposable element involved in dosage compensation in males on the evolutionarily new neo-X chromosome of
Drosophila miranda
. A particular copy of this transposable element has been inserted at chromatin entry sites on the neo-X chromosome that favorably binds to the male-specific lethal complex, which in turn facilitates the spreading of chromatin silencing on a single chromosome to provide dosage compensation.
Publisher
American Association for the Advancement of Science (AAAS)
Cited by
160 articles.
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