Drugging DNA repair-Reference-Cited by-同舟云学术

Drugging DNA repair

Published:2016-06-03 Issue:6290 Volume:352 Page:1178-1179
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Jackson Stephen P.¹²,Helleday Thomas³

Affiliation:

1. The Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Biochemistry, University of Cambridge, Cambridge CB2 1QN, UK.

2. The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

3. Science for Life Laboratory, Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S-171 21 Stockholm, Sweden.

Abstract

Inhibiting DNA repair can have a positive outcome on therapeutic interventions

Funder

KuDOS Pharmaceuticals

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference14 articles.

1. Instability and decay of the primary structure of DNA

2. The DNA-damage response in human biology and disease

3. Exploiting replicative stress to treat cancer

4. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

5. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

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