CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses-Reference-Cited by-同舟云学术

CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses

Published:2023-02-17 Issue:6633 Volume:379 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

He Mingyu¹^ORCID,Roussak Kate¹^ORCID,Ma Feiyang²^ORCID,Borcherding Nicholas¹^ORCID,Garin Vince¹,White Mike¹^ORCID,Schutt Charles¹^ORCID,Jensen Trine I.³^ORCID,Zhao Yun¹^ORCID,Iberg Courtney A.¹^ORCID,Shah Kairav¹^ORCID,Bhatia Himanshi¹^ORCID,Korenfeld Daniel¹^ORCID,Dinkel Sabrina¹^ORCID,Gray Judah¹^ORCID,Ulezko Antonova Alina¹^ORCID,Ferris Stephen¹^ORCID,Donermeyer David¹^ORCID,Lindestam Arlehamn Cecilia⁴^ORCID,Gubin Matthew M.¹^ORCID,Luo Jingqin⁵^ORCID,Gorvel Laurent¹^ORCID,Pellegrini Matteo²^ORCID,Sette Alessandro⁴⁶^ORCID,Tung Thomas⁷^ORCID,Bak Rasmus³⁸,Modlin Robert L.⁹¹⁰^ORCID,Fields Ryan C.⁴^ORCID,Schreiber Robert D.¹^ORCID,Allen Paul M.¹,Klechevsky Eynav¹^ORCID

Affiliation:

1. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Molecular Cell and Developmental Biology at University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.

3. Department of Biomedicine, Aarhus University, 8000 Aarhus C, Denmark.

4. Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.

5. Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

6. Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego (UCSD), La Jolla, CA 92037, USA.

7. Department of Surgery, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.

8. Aarhus Institute of Advanced Studies (AIAS), Aarhus University, 8000 Aarhus C, Denmark.

9. Division of Dermatology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

10. Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

Abstract

The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB) therapy. Here, we show that human CD1c + CD5 + DCs are reduced in melanoma-affected lymph nodes, with CD5 expression on DCs correlating with patient survival. Activating CD5 on DCs enhanced T cell priming and improved survival after ICB therapy. CD5 + DC numbers increased during ICB therapy, and low interleukin-6 (IL-6) concentrations promoted their de novo differentiation. Mechanistically, CD5 expression by DCs was required to generate optimally protective CD5 hi T helper and CD8 + T cells; further, deletion of CD5 from T cells dampened tumor elimination in response to ICB therapy in vivo. Thus, CD5 + DCs are an essential component of optimal ICB therapy.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Link

https://www.science.org/doi/pdf/10.1126/science.abg2752

Reference100 articles.

1. Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

2. Cancer immunotherapy comes of age

3. Taking dendritic cells into medicine

4. Restricted dendritic cell and monocyte progenitors in human cord blood and bone marrow

5. Functional Diversity of Human Dendritic Cells

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