A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568-Reference-Cited by-同舟云学术

A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568

Published:2017-05-19 Issue:6339 Volume:356 Page:757-759
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Yang Peng¹^ORCID,Wang Yixuan¹²,Hoang Don¹^ORCID,Tinkham Matthew¹^ORCID,Patel Anamika³^ORCID,Sun Ming-An¹^ORCID,Wolf Gernot¹^ORCID,Baker Mairead¹,Chien Huan-Chieh⁴⁵^ORCID,Lai Kuan-Yu Nick⁴⁵^ORCID,Cheng Xiaodong³,Shen Che-Kun James⁴⁵^ORCID,Macfarlan Todd S.¹^ORCID

Affiliation:

1. The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

2. Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

3. Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA.

4. Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China.

5. Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China.

Abstract

Embryo viability relies on placental repression The insulin-like growth factor (IGF) signaling pathway controls maternal supply of and fetal demands for nutrients. Yang et al. report that the essential KRAB–zinc finger protein ZFP568 specifically and directly represses a placental-specific IGF2 transcript during early mouse development. Elimination of ZFP568 in vivo leads to the inappropriate early activation of transcription, which results in embryonic death owing to overexpression of IGF2 peptide. Thus, the specific, targeted preimplantation repression of a promoter is essential for viability. Science , this issue p. 757

Funder

National Institutes of Health

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Natural Science Foundation of China

MOST Frontier of Science Award

Future Scientists Exchange Program of CSC

Academia Sinica Senior Investigator Award

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference25 articles.