Ebola and beyond

Author:

Lipsitch Marc1,Eyal Nir2,Halloran M. Elizabeth34,Hernán Miguel A.5,Longini Ira M.6,Perencevich Eli N.78,Grais Rebecca F.9

Affiliation:

1. Center for Communicable Disease Dynamics and Departments of Epidemiology and Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.

2. Department of Global Health and Population, Harvard T. H. Chan School of Public Health and Center for Bioethics, Harvard Medical School, Boston, MA, USA.

3. Center for Inference and Dynamics of Infectious Diseases, Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

4. Department of Biostatistics, University of Washington, Seattle, WA 98105, USA.

5. Center for Communicable Disease Dynamics and Departments of Epidemiology and Biostatistics, Harvard T. H. Chan School of Public Health, and Harvard-MIT Division of Health Sciences and Technology, Boston, MA, USA.

6. Center for Inference and Dynamics of Infectious Diseases, Department of Biostatistics, College of Public Health and Health Professions, and College of Medicine, University of Florida, Gainesville, FL, USA.

7. Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA.

8. Center for Comprehensive Access and Delivery Research and Evaluation, Iowa Veterans Affairs Health Care System, Iowa City, IA, USA.

9. Epicentre, Paris, France.

Abstract

Recent experiences in confronting the Ebola epidemic suggest principles for vaccine efficacy trials in challenging environments

Funder

National Institute of General Medical Sciences

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference16 articles.

1. WHO high-level meeting on Ebola vaccines access and financing 23 October 2014 ; http://apps.who.int/iris/bitstream/10665/137184/1/WHO_EVD_Meet_EMP_14.2_eng.pdf?ua=1&ua=1

2. Giahyue J. H. Liberia begins clinical trial for Ebola vaccines as outbreak ebbs. Reuters 2 February 2015 ; www.reuters.com/article/2015/02/02/health-ebola-vaccines-idUSL6N0VC2AE20150202 (2015).

3. Maxmen A. Why we're still waiting on an Ebola vaccine. Al Jazeera America 11 March 2015 ; http://america.aljazeera.com/articles/2015/3/11/why-were-still-waiting-on-an-ebola-vaccine.html

4. SAGE Working Group on Vaccination in Acute Humanitarian Emergencies, Vaccination in acute humanitarian emergencies: A framework for decisionmaking (WHO, Geneva, 2013; www.who.int/iris/handle/10665/92462

5. Randomised controlled trials for Ebola: practical and ethical issues

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