Social status alters immune regulation and response to infection in macaques

Author:

Snyder-Mackler Noah12,Sanz Joaquín34,Kohn Jordan N.5,Brinkworth Jessica F.36,Morrow Shauna1,Shaver Amanda O.1,Grenier Jean-Christophe4,Pique-Regi Roger78,Johnson Zachary P.59,Wilson Mark E.510,Barreiro Luis B.411,Tung Jenny1121314

Affiliation:

1. Department of Evolutionary Anthropology, Duke University, Durham, NC 27708, USA.

2. Duke Center for the Study of Aging and Human Development, Duke University, Durham, NC 27708, USA.

3. Department of Biochemistry, Faculty of Medicine, Université de Montréal, Montréal, Quebec H3T1J4, Canada.

4. Department of Genetics, Centre Hospitalier Universitaire Sainte-Justine Research Center, Montréal, Quebec H3T1C5, Canada.

5. Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA.

6. Department of Anthropology, University of Illinois at Urbana–Champaign, Urbana, IL 61801, USA.

7. Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI 48201, USA.

8. Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI 48201, USA.

9. Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA.

10. Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA.

11. Department of Pediatrics, Faculty of Medicine, Université de Montréal, Montréal, Quebec H3T1J4, Canada.

12. Department of Biology, Duke University, Durham, NC 27708, USA.

13. Institute of Primate Research, National Museums of Kenya, Nairobi 00502, Kenya.

14. Duke Population Research Institute, Duke University, Durham, NC 27708, USA.

Abstract

Status alters immune function in macaques Rhesus macaques experience variable levels of stress on the basis of their position in the social hierarchy. To examine how stress affects immune function, Snyder-Mackler et al. manipulated the social status of individual macaques (see the Perspective by Sapolsky). Social status influenced the immune system at multiple levels, from immune cell numbers to gene expression, and altered signaling pathways in a model of response to infection. Macaques possess a plastic and adaptive immune response wherein social subordination promotes antibacterial responses, whereas high social status promotes antiviral responses. Science , this issue p. 1041 ; see also p. 967

Funder

NIH

NSF

Canada Research Chairs Program

NSERC

Fonds de recherche du Quebec

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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