Molecular architecture of the active mitochondrial protein gate-Reference-Cited by-同舟云学术

Molecular architecture of the active mitochondrial protein gate

Published:2015-09-25 Issue:6255 Volume:349 Page:1544-1548
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Shiota Takuya¹²,Imai Kenichiro³,Qiu Jian⁴,Hewitt Victoria L.¹,Tan Khershing¹,Shen Hsin-Hui¹,Sakiyama Noriyuki³,Fukasawa Yoshinori³,Hayat Sikander⁵,Kamiya Megumi²,Elofsson Arne⁵,Tomii Kentaro³,Horton Paul³,Wiedemann Nils⁴⁶,Pfanner Nikolaus⁴⁶,Lithgow Trevor¹,Endo Toshiya²⁷

Affiliation:

1. Biomedicine Discovery Institute and Department of Microbiology, Monash University, Melbourne, Victoria 3800, Australia.

2. Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.

3. Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology, 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.

4. Institut für Biochemie und Molekularbiologie, Universität Freiburg, 79104 Freiburg, Germany.

5. Department of Biochemistry and Biophysics and Science for Life Laboratory, Stockholm University, Box 1031, 17121 Solna, Sweden.

6. Centre for Biological Signalling Studies, Universität Freiburg, 79104 Freiburg, Germany.

7. Faculty of Life Sciences, Kyoto Sangyo University, Kamigamo-motoyama, Kita-ku, Kyoto 603-8555, Japan.

Abstract

Dissecting the mitochondrial entry portal Mitochondria, the powerhouses of the cell, are mainly composed of proteins made in the cytosol. These newly synthesized proteins need to be imported across the organelle's membrane through dedicated protein import machinery. Shiota et al. have worked out the architecture and mechanism of the mitochondrial protein import channel. Science , this issue p. 1544

Funder

Japan Agency for Medical Research and Development

Deutsche Forschungsgemeinschaft

Japan Society for the Promotion of Science (JSPS)

Ministry of Education, Culture, Sports, Science and Technology

Swedish Foundation for Strategic Research

Japan Science and Technology Agency (JST)

Scientific Research on Innovative Areas

Strategic Japanese-Swedish Cooperative Program

Publisher

American Association for the Advancement of Science (AAAS)

Subject