Transcriptome-wide distribution and function of RNA hydroxymethylcytosine-Reference-Cited by-同舟云学术

Transcriptome-wide distribution and function of RNA hydroxymethylcytosine

Published:2016-01-15 Issue:6270 Volume:351 Page:282-285
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Delatte Benjamin¹,Wang Fei²,Ngoc Long Vo³,Collignon Evelyne¹,Bonvin Elise¹,Deplus Rachel¹,Calonne Emilie¹,Hassabi Bouchra¹,Putmans Pascale¹,Awe Stephan⁴,Wetzel Collin⁵,Kreher Judith⁴,Soin Romuald³,Creppe Catherine¹,Limbach Patrick A.⁵,Gueydan Cyril³,Kruys Véronique³,Brehm Alexander⁴,Minakhina Svetlana²,Defrance Matthieu¹,Steward Ruth²,Fuks François¹

Affiliation:

1. Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Université Libre de Bruxelles (ULB), Brussels, Belgium.

2. Waksman Institute, Department of Molecular Biology and Biochemistry, Cancer Institute of New Jersey, Rutgers University, Piscataway, NJ, USA.

3. Laboratory of Molecular Biology of the Gene, Faculty of Sciences, Université Libre de Bruxelles, Gosselies, Belgium.

4. Institut für Molekularbiologie und Tumorforschung, Philipps-Universität Marburg, Marburg, Germany.

5. Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA.

Abstract

Chemical modification of RNA for function Chemical modifications play an important role in modifying and regulating the function of DNA and RNA. Delatte et al. show that, in the fruit fly, many messenger RNAs (mRNAs) contain the modified base 5-hydroxymethylcytosine (5hmC). The chemical mark is added by the same enzyme that adds 5hmC to DNA. Because many mRNAs involved in neuronal development contain 5hmC, blocking the enzyme causes brain defects and is lethal. In vivo, RNA hydroxymethylation promotes mRNA translation. Science , this issue p. 282

Funder

Belgian Fonds de la Recherche Scientifique (FNRS)

Belgian American Educational Foundation (BAEF)

WBHealth

Action de Recherche Concertee (ARC)

Belgian Fondation contre le Cancer

Fonds Gaston Ithier

NIH

ARC

Brachet and Van Buuren Funds

National Science Foundation

Publisher