A Mutation in Hairless Dogs Implicates FOXI3 in Ectodermal Development-Reference-Cited by-同舟云学术

A Mutation in Hairless Dogs Implicates FOXI3 in Ectodermal Development

Published:2008-09-12 Issue:5895 Volume:321 Page:1462-1462
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Drögemüller Cord¹²³⁴⁵,Karlsson Elinor K.¹²³⁴⁵,Hytönen Marjo K.¹²³⁴⁵,Perloski Michele¹²³⁴⁵,Dolf Gaudenz¹²³⁴⁵,Sainio Kirsi¹²³⁴⁵,Lohi Hannes¹²³⁴⁵,Lindblad-Toh Kerstin¹²³⁴⁵,Leeb Tosso¹²³⁴⁵

Affiliation:

1. University of Berne, 3001 Berne, Switzerland.

2. Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

3. Institute of Biomedicine, 00014 Helsinki, Finland.

4. University of Helsinki, 00014 Helsinki, Finland.

5. Uppsala University, 75124 Uppsala, Sweden.

Abstract

Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102–kilo–base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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