Nucleocytoplasmic Shuttling of a GATA Transcription Factor Functions as a Development Timer-Reference-Cited by-同舟云学术

Nucleocytoplasmic Shuttling of a GATA Transcription Factor Functions as a Development Timer

Published:2014-03-21 Issue:6177 Volume:343 Page:
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Cai Huaqing¹,Katoh-Kurasawa Mariko²,Muramoto Tetsuya³,Santhanam Balaji⁴,Long Yu¹,Li Lei⁵,Ueda Masahiro³⁶,Iglesias Pablo A.¹⁷,Shaulsky Gad²⁴,Devreotes Peter N.¹

Affiliation:

1. Department of Cell Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

2. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

3. Laboratory for Cell Signaling Dynamics, RIKEN Quantitative Biology Center, Osaka 565-0874, Japan.

4. Graduate Program in Structural Computational Biology and Molecular Biophysics, Baylor College of Medicine, Houston, TX 77030, USA.

5. Department of Biology, University of Virginia, Charlottesville, VA 22904, USA.

6. Department of Biological Sciences, Graduate School of Science, Osaka University, Osaka 565-0043, Japan.

7. Department of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.

Abstract

Oscillate to Synchronize In the social amoeba Dictyostelium discoideum , periodic waves of the small-molecule cyclic adenosine monophosphate (cAMP) guide chemotactic migration and cell differentiation. Cai et al. ( 10.1126/science.1249531 ; see the Perspective by

Wollman

) found that a GATA family transcription factor shuttles between the nucleus and the cytoplasm of the amoeba in response to oscillatory cAMP signals acting through G protein–coupled receptors. Each oscillation generates a transient burst of gene activation, such that gene expression is linked to the number rather than the level of stimulus, which then brings about transcriptional synchrony in populations of cells.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

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