Chromosome errors in human eggs shape natural fertility over reproductive life span

Author:

Gruhn Jennifer R.1ORCID,Zielinska Agata P.2ORCID,Shukla Vallari1ORCID,Blanshard Robert34ORCID,Capalbo Antonio5,Cimadomo Danilo6,Nikiforov Dmitry78ORCID,Chan Andrew Chi-Ho1,Newnham Louise J.3,Vogel Ivan1,Scarica Catello9,Krapchev Marta10ORCID,Taylor Deborah11ORCID,Kristensen Stine Gry7ORCID,Cheng Junping7,Ernst Erik12,Bjørn Anne-Mette Bay12,Colmorn Lotte Berdiin13,Blayney Martyn14,Elder Kay14ORCID,Liss Joanna1015ORCID,Hartshorne Geraldine11ORCID,Grøndahl Marie Louise16,Rienzi Laura6,Ubaldi Filippo6,McCoy Rajiv17ORCID,Lukaszuk Krzysztof101819ORCID,Andersen Claus Yding7,Schuh Melina2ORCID,Hoffmann Eva R.1ORCID

Affiliation:

1. DNRF Center for Chromosome Stability, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

2. Max Planck Institute for Biophysical Chemistry, Department of Meiosis, Göttingen, Germany.

3. Genome Damage and Stability Centre, School of Life Sciences, University of Sussex, Brighton, UK.

4. Illumina Inc., Fulbourn, UK.

5. Igenomix, Marostica, Italy.

6. G.en.e.r.a., Centers for Reproductive Medicine, Clinica Valle Giulia, via de notaris 2b, 00197 Rome, Italy.

7. Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Hospital and Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

8. Unit of Basic and Applied Biosciences, Università degli studi di Teramo, Teramo, Italy.

9. DAHFMO, Unit of Histology and Medical Embryology, Sapienza, University of Rome, Italy.

10. INVICTA Fertility and Reproductive Center, Gdańsk, Poland.

11. Warwick Medical School, University of Warwick and Centre for Reproductive Medicine, University Hospital Coventry, UK.

12. Department of Obstetrics and Gynaecology, University Hospital of Aarhus, Skejby Sygehus, Aarhus, Denmark.

13. The Fertility Clinic, The Juliane Marie Centre for Women, Children and Reproduction, Copenhagen University Rigshospitalet, Denmark.

14. Bourn Hall Clinic, Cambridge, UK.

15. Department of Biology and Medical Genetics, University of Gdańsk, Gdańsk, Poland.

16. Department of Obstetrics and Gynaecology, Department of Reproductive Medicine, Copenhagen University Hospital Herlev, Denmark.

17. Department of Biology, Johns Hopkins University, Baltimore, MD, USA.

18. Department of Obstetrics and Gynaecological Nursing, Faculty of Health Sciences, Medical University of Gdańsk, Gdańsk, Poland.

19. Department of Gynaecological Endocrinology, Medical University of Warsaw, Warsaw, Poland.

Abstract

Understanding fertility in young and old Fertility in humans follows a U-curve, with low rates in both teenagers and women of advancing maternal age (mid-30s and above). Gruhn et al. found that this distinct shape originates from chromosomal errors in human eggs, which result in genomic imbalance and pregnancy loss. The error types and chromosomes affected in the young and advanced age groups were different, suggesting that two distinct chromosome-based mechanisms balance risk associated with pregnancy and evolutionary fitness as women enter and exit their reproductive life span. The authors show that chromosome structure erodes only with advancing age, acting as a “molecular clock” for reproductive senescence. Science , this issue p. 1466

Funder

Medical Research Council

European Research Council

Danish National Research Foundation

Carlsbergfondet

Novo Nordisk Fonden

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3