Affiliation:
1. Skaggs Institute for Chemical Biology and Department of Chemistry, Scripps Research Institute, La Jolla, CA 92037, USA.
Abstract
Multiple copies of a molecule, held together in finite aggregates, give rise to properties and functions that are unique to their assembled states. Because these aggregates are held together by weak forces operating over short distances, a premium is placed on complementarity: The molecular surfaces must facilitate specific interactions that direct the assembly to one aggregate rather than another. Hydrogen-bonding preferences can be combined with molecular curvature to favor the assembly of four self-complementary subunits into a pseudo-spherical capsule. Filling the capsule with smaller, complementary molecules provides the final instruction for the assembly process.
Publisher
American Association for the Advancement of Science (AAAS)
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